High Molecular Weight Sodium Hyaluronate Food Grade High Purity
High Molecular Weight Sodium Hyaluronate Food Grade High Purity
Food Grade High HA Sodium Hyaluronate 400-600kDa
High Molecular Weight Sodium Hyaluronate (HA-F) is a premium, food-grade sodium hyaluronate with a molecular weight of 400–600 kDa and HA content ≥96%. Hyaluronic acid (HA) is a naturally occurring acidic polysaccharide widely distributed in human dermal tissue, composed of repeating disaccharide units of N-acetylglucosamine and D-glucuronic acid, forming linear polysaccharides. One gram of HA can bind up to 1000 times its weight in water, making it one of the most effective natural moisturizers known.
Unlike topical HA, which only affects the skin surface, oral HA supplementation replenishes the body’s internal HA, acting as a “second-generation nutrient.” It is absorbed through the gastrointestinal mucosa into the bloodstream and utilized by various organs and tissues. High molecular HA forms a unique three-dimensional structure that supports collagen and elastin synthesis in the dermis, maintains hydration, delays aging, enhances joint health, supports cardiovascular and brain function, and boosts overall immunity.
Applications include: otolaryngology, oncology, dentistry, wound healing, dietary supplements, ophthalmology, urology, skincare, orthopedics, soft tissue filling, and respiratory medicine.
Description

Product Overview:
Product Name: High Molecular Weight Sodium Hyaluronate (HA-F)
Molecular Weight: 400–600 kDa
Appearance: White crystalline powder
HA Content: ≥96%
Glucuronic Acid Content: ≥46%
pH Value: 6–7
Protein Content: <0.05%
Heavy Metals: As <0.01ppm, Pb <0.02ppm
Endotoxin Level: 0.07 EU/mg (well below pharmacopoeia limits)
Shelf Life: 24 months under dry, cool storage
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Item | Standard |
| Appearance | White Powder | |
| PH | 6.0-8.0 | |
| Transparency | ≥99.0% | |
| Loss Ondrying | ≤8.0% | |
| Bulk Density | Practical Value | |
| Molecular Weight | Practical Value | |
| Bacterial Endotoxin | <0.5EU/mg | |
| Residue On Ignition | ≤13.0% | |
| Heavy Metals | ≤20ppm | |
| Arsenic | ≤20ppm | |
| Glucuronic Acid | ≥44.0% | |
| HA | ≥96.0% | |
| Bacterial Counts | ≤100cfu/g | |
| Mold & Yeast | <10cfu/g | |
| E.Coli | Negative | |
| Staphylococcus Aureus | Negative | |
| Salmonella | Negative |
Key benefits of oral high molecular HA:
1.Skin: Improves elasticity, smoothness, reduces wrinkles.
2.Eyes: Maintains eye moisture, alleviates dryness and irritation.
3.Brain: Supports osmotic balance and neural tissue nutrition.
4.Joints: Acts as a natural shock absorber, relieving inflammation and pain.
5.Gastrointestinal: Protects and improves gut lining and digestion.
6.Healing: Accelerates wound recovery.
7.Antimicrobial: Forms a natural barrier against pathogens.
8.Immunity & Energy: Maintains bodily functions and vitality.
9.Cardiovascular & Brain Health: Helps prevent atherosclerosis, arrhythmia, and brain atrophy.
HA is widely used in beverages, dairy products, functional foods, capsules, tablets, and liquid formulations, often in combination with collagen, vitamins, glucosamine, or chondroitin sulfate.
Certifications & Quality Assurance:
Kosher & Halal Certified
ISO 9001 / GMP Compliant
Non-GMO, low heavy metals, low endotoxin, high stability
| Food Grade Sodium Hyaluronate | |||
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| ltem | Product Code | Molecular Weight | Function |
| Sodium Hyaleronate | HA-F | 100kDa~200kDa | anti-aging,reduce inflam-mation,lubricate joints,flooding-pain and sooth wrinkle |
| 200kDa~400kDa | |||
| 400kDa~600kDa | |||
Why Choose Us:
1.Highly stable HA with minimal batch variation
2.Real measured molecular weight for accurate product selection
3.Excellent solubility and clarity without yellowing
4.Global supply capability with OEM/ODM services
5.Sterile production ensuring safety and consistency
Our Product Features:
1.Excellent hydrolysis stability; viscosity remains unchanged after 3–5 days at normal conditions.
2.High HA content (≥96%) with glucuronic acid ≥46%, exceeding industry standards.
3.True molecular weight labeling for easy selection and time-efficient comparison.
4.Stable pH (6–7) and very low protein (<0.05%) to prevent allergenic reactions.
5.Extremely low heavy metals and endotoxin levels, far below regulatory limits.
6.Pure white powder, dissolves to clear, transparent solution, superior to competitors prone to yellowing.
How to Judge HA Quality:
1.Appearance: pure white, fine, free of black particles.
2.Sterile production conditions; low microbial counts.
3.Uniform particle size; no oversized particles due to improper dehydration.
4.Solution transparency: clear and colorless; higher transparency indicates higher purity.
5.Glucuronic acid content: an important indicator of HA concentration.
6.Protein content: low levels to reduce allergenic risks.
Storage & Handling:
1.Store in a cool, dry, sealed, and dark environment.
2.Avoid cationic surfactants to prevent precipitation.
3.Dissolve in sterilized distilled or deionized water, temperature ≤60℃.
4.After opening, residual powder should be sealed in sterile conditions.
5.Use preservatives if not consumed immediately after dissolution.
Frequently Asked Questions (FAQ) — High Molecular Weight Sodium Hyaluronate (HA-F)
1. What is High Molecular Weight Sodium Hyaluronate (HA-F)?
High Molecular Weight Sodium Hyaluronate (HA-F) is a premium, food-grade form of sodium hyaluronate with a molecular weight range of 400–600 kDa and purity ≥96%. It is derived from hyaluronic acid (HA) — a natural polysaccharide found in human skin, joints, and connective tissue — known for its exceptional water-binding and moisturizing abilities.
2. How is HA-F different from Low or Medium Molecular Weight Sodium Hyaluronate?
High molecular weight HA-F has larger molecules that form a strong hydration film and provide long-lasting moisture retention and viscoelasticity.
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High MW (400–600 kDa): ideal for joint health, anti-aging, and tissue regeneration.
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Medium MW (200–400 kDa): supports skin elasticity and hydration.
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Low MW (<200 kDa): promotes absorption and biological activity in cells.
3. How does orally ingested sodium hyaluronate work in the body?
Unlike topical HA, which hydrates only the skin’s surface, oral HA is absorbed through the intestinal mucosa into the bloodstream. It is then distributed to the skin, joints, eyes, and connective tissues, helping to restore the body’s natural HA levels, enhance hydration, and support joint and skin health from within.
4. What are the key benefits of High Molecular Weight HA-F?
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Deep hydration and moisture retention
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Supports collagen and elastin synthesis
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Promotes joint lubrication and flexibility
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Enhances skin elasticity and smoothness
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Helps delay visible aging signs
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Supports cardiovascular, brain, and immune functions
5. What are the typical applications of HA-F?
HA-F is widely used in:
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Dietary supplements and functional foods
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Cosmeceuticals and skin hydration formulas
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Joint and bone health products
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Wound healing and tissue repair formulations
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Ophthalmic, urological, and orthopedic products
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Soft tissue filling and respiratory care
6. What is the recommended dosage for oral HA?
Typical oral supplementation ranges from 50 mg to 200 mg per day, depending on the desired application and formulation. Actual dosage should be determined according to product formulation and regulatory guidelines in the target market.
7. Is HA-F safe for human consumption?
Yes. HA-F is food-grade, non-toxic, and biocompatible, meeting international safety standards. It is derived from non-animal fermentation sources and produced under GMP and ISO-certified facilities to ensure purity and quality.
8. Can HA-F be combined with other functional ingredients?
Absolutely. HA-F works synergistically with collagen peptides, vitamin C, ceramides, astaxanthin, and coenzyme Q10 to enhance hydration, skin elasticity, and overall anti-aging effects.
9. What is the shelf life and storage condition of HA-F?
Shelf life: 24 months under proper conditions.
Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Seal tightly after opening.
10. What packaging options are available?
Standard packaging: 1 kg aluminum foil bag, 10 bags per 10 kg carton, or customized packaging available upon request.







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