Description

Product Name: Acetylated Sodium Hyaluronate
Molecular Weight Range: 20,000–50,000 Da
Appearance: White or off-white powder, odorless, lipophilic & oleophilic
Molecular Formula: (C14 + 2×H2O + 2×NO11 + xNa)n (x = degree of acetylation)
INCI Name: Sodium Acetylated Hyaluronate
Functions: Deep hydration, oil-phase moisture lock, barrier repair, enhanced skin elasticity, protection against HA degradation, suitable for oil-based skincare and medical applications
Specifications: 100g/bottle, 1kg/aluminum foil bag
Certifications: cGMP, ISO 9001, ISO 22000, ISO 13485, HACCP, Halal, FSSC 22000, FDA, REACH, COSMOS

Product Features:
1.Oil-Phase Empowerment: Solves precipitation and deactivation issues in oil-based formulations, enabling broader application possibilities.
2.Deep Skin Penetration: Reaches 100μm depth in the skin, ensuring more effective hydration and barrier repair than standard HA.
3.Hyaluronidase Resistance: 13× higher resistance than standard HA, protecting dermal structure from enzymatic degradation and intrinsic aging.
4.Dual-Phase Hydration: Amphiphilic structure provides simultaneous water- and oil-phase moisturizing.
5.Improved Elasticity & Skin Texture: Enhances skin softness, elasticity, and smoothness, reducing dryness and roughness.
6.High Purity & Stability: Effective substance content >95%, consistent quality for high-end formulations.

	Inspection Item	Specification
	Appearance	White to light yellow powder or particles, dissolves clear
	Acetyl Content (%)	23.0–29.0
	Intrinsic Viscosity (dL/g)	0.50–2.80
	Transmittance of Solution (%)	≥99.0
	Loss on Drying (%)	≤10.0
	pH (5mg/mL, 25℃)	5.0–7.0
	Heavy Metals (as Pb, mg/kg)	≤20
	Burning Residue (%)	11.0–16.0
	Protein Content (%)	≤0.10
	Total Bacterial Count (CFU/g)	≤100
	Mold & Yeast (CFU/g)	≤50
	Staphylococcus aureus (CFU/g)	Not detectable
	Pseudomonas aeruginosa (CFU/g)	Not detectable

 

Quality Assurance:
Each batch undergoes strict in-house and third-party testing, including molecular weight, degree of acetylation, solubility, and appearance. Manufactured under ISO, GMP, and HACCP-compliant facilities, ensuring traceable, stable, and reliable quality.

Storage & Handling:
Store in a cool, dry place, away from light and moisture. Keep the container tightly closed. Avoid contamination during use. Recommended shelf life: 24 months under proper storage conditions.

Cationic HA vs Acetylated HA – Comparison Table

Feature	Cationic Sodium Hyaluronate (cHA)	Acetylated Sodium Hyaluronate (AcHA)
Charge	Positive (cationic)	Neutral/lipophilic (acetyl-modified)
Skin/Hair Affinity	Strong adhesion to negatively charged skin and hair; resistant to rinsing	High skin penetration and adhesion due to lipophilic acetyl groups
Primary Function	Hair & scalp hydration, film-forming protection	Skin moisturizing, barrier repair, elasticity enhancement
Water Retention	High, mainly on hair & skin surface	Double hydration in stratum corneum, long-lasting skin hydration
Film Formation	Forms protective layer on hair & scalp	Forms dense hydration layer on skin; improves barrier function
Suitable Applications	Shampoos, conditioners, hair masks, body wash	Serums, creams, lotions, facial masks, anti-aging skincare
Bioactivity	Moderate	High, enhances cell proliferation & barrier repair
Formulation Compatibility	Avoid cationic surfactants or preservatives	Compatible with surfactants, peptides, actives
Key Advantages	Resistant to rinsing, silky hair feel	Deep skin hydration, repair dry/damaged skin, improves elasticity

 

Applications:
1.High-End Skincare & Personal Care: Facial oils, creams, sunscreens, serums for deep hydration and anti-aging
2.Medical Oil-Based Dressings: Supports skin repair and moisture retention in oil-based therapeutic formulations
3.Cosmetic Formulations: Enhances texture, elasticity, and barrier protection in emulsion and oil-phase products

Why Choose Our Acetylated Sodium Hyaluronate?
1.Patented Technology: Targeted acetylation process precisely controls substitution degree and molecular weight distribution.
2.Oil-Phase Innovation: Expands HA applications to oil-based formulations without precipitation or activity loss.
3.Proven Safety & Efficacy: Laboratory and skin penetration studies validate deeper hydration, enzyme resistance, and barrier repair.
4.Customizable Solutions: Support for tailored molecular weights and blended formulations.
5.Global Recognition: Multiple international certifications guarantee product safety, compliance, and reliability for worldwide distribution.

Acetylated Sodium Hyaluronate (20,000–50,000 Da) FAQ

1. What is Acetylated Sodium Hyaluronate?
Acetylated Sodium Hyaluronate is a next-generation derivative of hyaluronic acid produced via targeted acetylation technology. It combines hydrophilic and lipophilic properties, enabling dual-phase hydration and enhanced skin barrier repair, unlike standard water-soluble HA.

2. What is the molecular weight and substitution degree of this product?
The molecular weight ranges from 20,000 to 50,000 Da. The substitution degree is precisely controlled during production to optimize skin penetration, moisture retention, and product performance.

3. How does Acetylated Sodium Hyaluronate differ from regular Sodium Hyaluronate?

• Amphiphilic structure: penetrates both water and oil phases.

• Enhanced enzyme resistance: 13× more resistant to hyaluronidase than standard HA.

• Deeper skin penetration: reaches up to 100μm, promoting improved hydration, elasticity, and skin barrier repair.

4. What are the main benefits for skin?

• Long-lasting hydration

• Improved skin elasticity and suppleness

• Enhanced barrier repair and protection against intrinsic aging

• Reduces dryness, roughness, and visible signs of aging

5. In what types of formulations can it be used?

• Oil-based skincare products: facial oils, creams, sunscreens

• Medical oil-based dressings and cosmetic treatments

• Dual-phase or hybrid emulsions where both water and oil solubility is required

6. How stable is the product in formulations?
The product is highly resistant to hyaluronidase and maintains stability in various cosmetic, oil-based, and aqueous formulations. Its amphiphilic properties ensure compatibility with a wide range of ingredients.

7. How should it be incorporated into formulations?

• Typically added during the oil or water phase depending on the product type.

• Recommended concentrations vary depending on application but are generally in the range of 0.1–2% for cosmetic and personal care products.

8. Is it safe and certified for global use?
Yes. Our products comply with international standards, including cGMP, ISO 9001, ISO 22000, ISO 13485, HACCP, Halal, FSSC 22000, FDA, REACH, and COSMOS. Each batch undergoes strict quality control to ensure safety, stability, and consistency.

9. Can it be customized for specific applications?
Yes. We offer both standard and customized Acetylated Sodium Hyaluronate and related derivatives to meet specific molecular weight, substitution degree, or functional requirements for cosmetics, personal care, nutrition, functional foods, pharmaceuticals, and research.

10. What packaging options are available?
Available in powder or solution form, packaged in moisture-proof containers, with options tailored for small-scale R&D to large-scale industrial production.