Description

Product Name:Rutin Cocrystals

Active Ingredient：Rutin

Active Content：≥60%

Recommended Dose：250–1000 mg

Technology：Co-crystal Technology

Product Form：Spherical Crystalline Powder

Key Advantage：Up to 40× Higher Solubility

Absorption：Up to 5× Higher Absorption vs. Conventional Rutin

Maximum Solubility Up to 2 mg/mL

Key Properties：High Water Solubility, Faster Dissolution, Good Flowability

Applications：Supplements, Functional Foods, Cosmetics, Advanced Formulations

 

1.Rutin Cocrystals — From Poorly Soluble Rutin to a High-Solubility Crystalline Form

Rutin is a naturally occurring flavonoid glycoside widely found in plants. Although it is a valuable natural active ingredient, conventional Rutin has a significant formulation limitation: poor water solubility.

Traditional Rutin has a water solubility of approximately 0.1 mg/mL, while its reported bioavailability is only around 4.9%. These characteristics can restrict its application in formulations where rapid dissolution and efficient absorption are important.

This is where Rutin Cocrystals provide a different technical approach.

Rather than simply adding a dispersant, emulsifier or conventional encapsulation system, Rutin is converted into a new crystalline form through Co-crystal Technology. This changes the solid-state properties of the ingredient while retaining the molecular identity of the active ingredient.

The result is a Rutin ingredient with substantially improved water solubility, faster dissolution and enhanced absorption potential.

 

2.What Are Rutin Cocrystals?

Cocrystals are crystalline materials formed by two or more solid components, typically an active pharmaceutical or functional ingredient and a coformer, which interact at the molecular level through non-covalent interactions in a defined ratio.

The formation mechanism is based on supramolecular self-assembly. Molecular interactions generate supramolecular networks, followed by molecular stacking, assembly and ordered arrangement into a three-dimensional crystal structure.

For Rutin, the Co-crystal Technology creates a specific crystalline form consisting of Rutin and an edible coformer.

This is fundamentally different from a physical blend.

It is also different from Microencapsulation, Liposomal Technology or ordinary powder processing. The improvement comes from solid-state engineering at the molecular and crystal-structure level.

The resulting Rutin Cocrystals are designed to improve key physicochemical properties such as:

• Solubility
• Dissolution rate
• Stability
• Physical properties
• Flowability
• Bioavailability

The active ingredient itself is not chemically modified into a new molecular entity; instead, its solid-state form and intermolecular organization are engineered through Co-crystal Technology.

 

3.Up to 40× Higher Solubility

The most important formulation advantage of Rutin Cocrystals is their dramatically improved water solubility.

Conventional Rutin has limited water solubility of approximately 0.1 mg/mL. Rutin Cocrystals can reach solubility of up to 2 mg/mL, representing an improvement of up to approximately 40× based on the supplied product data.

This improvement can be particularly valuable for product developers working with:

• Water-based nutritional formulations
• Functional powders
• Tablets
• Gummies
• Solid beverages
• Advanced dietary supplement formulations

Higher solubility also provides greater flexibility when designing finished products where conventional Rutin may present dissolution or dispersion challenges.

 

4.   5× Higher Absorption Compared with Conventional Rutin

Improving solubility is only part of the formulation challenge. The ability of an active ingredient to dissolve efficiently is closely connected with its potential absorption.

Rutin Cocrystals provide up to 5× higher absorption compared with conventional Rutin, according to the supplied product data.

This makes Rutin Cocrystals particularly attractive for formulators looking for a more efficient Rutin ingredient rather than simply increasing the amount of conventional Rutin powder.

For product developers, this creates additional formulation flexibility around:

• Active dosage
• Finished-product size
• Dissolution performance
• Formulation efficiency
• Delivery format

The specific finished-product performance will depend on the complete formulation and dosage form.

 

5.Faster Dissolution for Modern Formulations

Rutin Cocrystals are designed to provide a faster dissolution rate than conventional Rutin.

This is an important distinction for formulators because poor solubility can lead to slow dissolution and inconsistent formulation behavior.

Through Co-crystal Technology, the molecular arrangement and crystal properties of Rutin are engineered to provide a more favorable dissolution profile.

For international ingredient buyers, this means Rutin Cocrystals can be considered when conventional Rutin is limited by:

Low water solubility → Slow dissolution → Limited formulation flexibility

Rutin Cocrystals provide an alternative technical route:

Co-crystal Engineering → Higher Solubility → Faster Dissolution → Improved Absorption

 

6.Spherical Crystalline Powder with Good Flowability

Rutin Cocrystals are supplied as a spherical crystalline powder, rather than conventional Rutin powder.

The engineered crystalline form provides good flowability, which can be advantageous during downstream formulation and processing.

This is particularly relevant for manufacturers producing:

• Tablets
• Capsules
• Gummies
• Powder formulations
• Functional food products

Good powder handling can help improve formulation consistency and processing efficiency, especially when working with high-active-content ingredients.

 

7.High Active Content — ≥60%

Rutin Cocrystals provide an active content of ≥60%, combining a relatively high active concentration with the improved physicochemical properties provided by Co-crystal Technology.

This gives product developers a more advanced Rutin raw material for formulations where both active content and formulation performance matter.

The recommended dosage range is 250–1000 mg, allowing formulators to select the appropriate level according to the intended product concept and formulation requirements.

 

8.Why Co-crystal Technology Matters for Rutin

The value of Rutin Cocrystals goes beyond simply making Rutin more soluble.

Co-crystal Technology is a solid-state formulation technology designed to improve the physicochemical properties of active ingredients without changing their molecular structure.

Depending on the active ingredient and coformer system, supramolecular interactions can be used to engineer properties including:

01 — Stability Enhancement
Improved resistance to environmental factors such as oxidation and light degradation.

02 — Physical Property Optimization
Potential improvement in melting behavior, hygroscopicity and mechanical properties.

03 — Solubility & Dissolution Enhancement
Improved water solubility and faster dissolution can help overcome formulation limitations of poorly soluble ingredients.

04 — Bioavailability Improvement
Improved dissolution and absorption characteristics can provide a more efficient delivery profile.

For Rutin, the most commercially important advantages are higher solubility, faster dissolution and improved absorption.

 

9.Rutin Cocrystals vs. Conventional Rutin

Property	Conventional Rutin	Rutin Cocrystals
Active Content	Conventional grade	≥60%
Solid Form	Conventional Rutin	Engineered Co-crystal Form
Water Solubility	Approx. 0.1 mg/mL	Up to 2 mg/mL
Solubility Improvement	—	Up to 40×
Absorption	Conventional	Up to 5× higher
Dissolution	Relatively limited	Faster dissolution
Powder Form	Conventional powder	Spherical crystalline powder
Flowability	Depends on grade	Good flowability
Technology	Conventional processing	Advanced Co-crystal Technology

 

10.Advanced Co-crystal Technology for Functional Ingredients

Our Rutin Cocrystals are developed through an advanced Co-crystal Technology approach that focuses on the relationship between molecular interaction, crystal structure and final formulation performance.

The general technical route can be understood as:

Rutin Selection → Coformer Selection → Molecular Interaction → Supramolecular Self-Assembly → Co-crystal Formation → Crystal Structure Engineering → Improved Physicochemical Properties → Finished-Product Application

This approach allows poorly soluble or difficult-to-formulate active ingredients to be considered from a different technical perspective.

Instead of relying solely on conventional powder processing or adding more formulation aids, Co-crystal Technology works directly with the solid-state structure of the active ingredient.

 

11.Advanced Ingredient Technology Platform

As a global supplier of nutritional ingredients and advanced ingredient technologies, we combine ingredient sourcing with technical evaluation and application-oriented development.

Our technology platform covers Co-crystal Technology, Co-amorphous Technology, Liposomal Technology, Microencapsulation Technology, Submicroencapsulation Technology, Microparticles, Pellet Technology and Granulation Technology, allowing different technical routes to be considered according to the characteristics of each active ingredient and target formulation.

For Rutin and other challenging active ingredients, this technology-oriented approach allows product developers to evaluate different formulation strategies based on the specific application requirements.

 

12.Applications

Rutin Cocrystals can serve as an advanced Rutin ingredient for a wide range of downstream applications, including:

• Dietary Supplements
• Functional Foods
• Nutritional Powders
• Tablets
• Hard Capsules
• Gummies
• Powder Formulations
• Functional Food Ingredients
• Cosmetic Formulations
• Advanced Nutraceutical Formulations

The improved solubility and dissolution profile makes Rutin Cocrystals particularly interesting for product concepts where conventional Rutin has limitations in water solubility or absorption.

 

13.Customized Rutin Development & OEM

Different markets and finished products may require different active concentrations, dosage forms or technical properties.

We can support Rutin-based customized development and OEM/ODM projects, including evaluation of:

• Active content requirements
• Co-crystal formulation
• Powder characteristics
• Solubility requirements
• Dissolution performance
• Dosage-form compatibility
• Application-specific processing

If your formulation currently uses conventional Rutin but is limited by poor solubility, slow dissolution or low absorption, Rutin Cocrystals can be evaluated as an alternative formulation route.

 

14.B2B Bulk Supply of Rutin Cocrystals

We supply Rutin Cocrystals for international B2B customers, supporting ingredient distributors, dietary supplement manufacturers, functional food companies, cosmetic formulators and product developers.

The product is positioned for customers looking for more than a conventional Rutin raw material — particularly those developing formulations where solubility, dissolution, absorption and powder performance are important.

Contact us to discuss Rutin Cocrystals, bulk supply, sample requirements or customized Co-crystal development.

 

15.Key Advantages

Rutin Cocrystals ≥60%

• Up to 40× higher solubility
• Solubility up to 2 mg/mL
• Up to 5× higher absorption
• Faster dissolution
• Spherical crystalline powder
• Good flowability
• High active content
• Advanced Co-crystal Technology
• Molecular-level supramolecular assembly
• Suitable for multiple dosage forms
• Suitable for international B2B ingredient supply
• Custom development available

 

FAQ

1.What are Rutin Cocrystals?
Rutin Cocrystals are an engineered crystalline form of Rutin produced through Co-crystal Technology, where Rutin and an edible coformer interact at the molecular level to form a defined crystalline structure.

2.How are Rutin Cocrystals different from conventional Rutin?
The major difference is the solid-state form. Rutin Cocrystals are designed to provide higher water solubility, faster dissolution and improved absorption compared with conventional Rutin.

3.What is the active content of Rutin Cocrystals?
The active Rutin content is ≥60%.

4.How much higher is the solubility?
Supplied product data indicates that Rutin Cocrystals can provide up to 40× higher solubility, with solubility reaching up to 2 mg/mL.

5.How much higher is the absorption?
Supplied product data reports up to 5× higher absorption compared with conventional Rutin.

6.Is Rutin Cocrystals a Microencapsulated Powder?
No. Rutin Cocrystals are based on Co-crystal Technology, a solid-state formulation technology. They should not be described as Microencapsulated Powder.

7.What dosage forms are suitable?
Rutin Cocrystals can be considered for tablets, hard capsules, gummies, powders and other functional formulations depending on the finished-product design.

8.Can you provide samples for formulation testing?
Yes. Samples can be arranged for customers who would like to evaluate Rutin Cocrystals in their own formulation and application system.