Description

Product Name: PDRN (Polydeoxyribonucleotide) API
Molecular Weight Range: 50-1500 kDa (with optimized distribution for enhanced bioavailability)
Appearance: White to off-white lyophilized powder or fibrous material
Functions:
1.Tissue Regeneration & Wound Healing: Stimulates fibroblast proliferation and collagen synthesis, accelerating tissue repair and wound closure
2.Anti-inflammatory Action: Modulates inflammatory cytokines and reduces prostaglandin synthesis, minimizing inflammation and discomfort
3.Angiogenesis Promotion: Enhances blood vessel formation through VEGF activation, improving tissue oxygenation and nutrient delivery
4.Cellular Energy Activation: Increases ATP production and cellular metabolism for enhanced tissue vitality and repair capacity
5.Skin Barrier Restoration: Strengthens skin barrier function and improves hydration through enhanced extracellular matrix components
6.Hair Growth Stimulation: Promotes hair follicle activation and prolongs anagen phase in trichological applications
Molecular Formula: (C₁₀H₁₂N₅O₇P·C₉H₁₂N₃O₇P)n
Molecular Weight: Typically 50-1500 kDa (precisely controlled distribution)

Our Product Superiority: Why Choose Us?

1. Scientifically Validated Bioactivity:
Our PDRN undergoes rigorous biological activity testing to ensure consistent performance in stimulating tissue regeneration. Through advanced purification techniques, we maintain the integrity of the DNA fragments, preserving their natural signaling capabilities and ensuring optimal receptor activation in target tissues. Each batch is validated for its ability to promote fibroblast proliferation and collagen synthesis in standardized cellular assays.

2. Comprehensive International Certifications:
We maintain the highest standards of quality and safety with ISO 9001, ISO 22000, HACCP, HALAL, GMPC, and U.S. GRAS certifications. This comprehensive certification portfolio demonstrates our commitment to manufacturing excellence and provides our global clients with the assurance of working with a reliable, audited supplier that meets international regulatory requirements across pharmaceutical, cosmetic, and nutraceutical markets.

3. Optimized Molecular Weight Distribution:
Unlike conventional PDRN products, our carefully controlled manufacturing process ensures an ideal molecular weight distribution that maximizes bioavailability and biological activity. The specific fractionation process preserves the therapeutic polynucleotide chains while eliminating inactive fragments, resulting in superior performance at lower concentrations in final formulations.

4. Multi-Industry Application Versatility:
Our PDRN API is specifically engineered for seamless integration across multiple product categories:
4.1Aesthetic Medicine: Mesotherapy, injectable skin boosters, and regenerative treatments
4.2Dermocosmetics: High-performance anti-aging serums, creams, and regenerative skincare
4.3Wound Care: Advanced dressings, healing gels, and post-procedural recovery products
4.4Nutraceuticals: Oral supplements for skin health and tissue regeneration
4.5Trichology: Hair growth stimulants and scalp regeneration treatments

5. Technical Expertise and Customization Support:
Our experienced technical team provides comprehensive support for formulation development, stability testing, and regulatory documentation. We offer customization options including specific molecular weight profiles, concentration optimization, and compatibility testing with various delivery systems to ensure your final product achieves optimal performance and market differentiation.

Packaging & Storage
1.Packaging: Our PDRN is packaged in sterile, nitrogen-filled glass vials with butyl rubber stoppers and aluminum seals. Primary packaging includes 100mg, 500mg, and 1g vials, with bulk quantities available in customized packaging configurations.
2.Storage: CRITICAL – Store at -20°C or below in a dedicated freezer. Protect from light and moisture. The container must remain sealed under inert atmosphere until use. Under these conditions, the product maintains stability for 36 months. Avoid repeated freeze-thaw cycles. For formulation use, reconstitute with sterile water for injection or appropriate solvent immediately before use.

Handling Instructions:
1.Always maintain the cold chain during storage and transportation
2.Allow the product to reach room temperature in sealed condition before opening
3.Use aseptic techniques during handling and reconstitution
4.Reconstitute immediately before use and avoid storing reconstituted solutions
5.For cosmetic applications, incorporate at the final stage of formulation under mild conditions

PDRN (Polydeoxyribonucleotide) – Frequently Asked Questions (FAQ)

1. What is PDRN (Polydeoxyribonucleotide)?
PDRN is a biopolymer composed of purified DNA fragments derived from natural sources such as salmon. It is widely used as a regenerative active ingredient in pharmaceutical and aesthetic formulations. PDRN promotes cellular repair, enhances tissue regeneration, and improves skin health through multiple biological pathways.

---

2. How does PDRN work in the body?
PDRN activates the adenosine A2A receptor pathway, stimulating cell growth, collagen synthesis, and angiogenesis. It also reduces inflammation and accelerates tissue healing, making it highly effective in regenerative and anti-aging treatments.

---

3. What are the main applications of PDRN?
PDRN is used in:

• Aesthetic medicine: Skin rejuvenation, mesotherapy, and injectable fillers.

• Regenerative medicine: Wound healing, tissue repair, and post-surgical recovery.

• Cosmetic formulations: Anti-aging creams, serums, and repair ampoules.

• Nutraceuticals: Cellular recovery and skin health supplements.

---

4. What is the molecular weight range of your PDRN?
Our Pharmaceutical Grade PDRN consists of DNA fragments ranging from 50 to 1500 kDa, precisely optimized for maximum biological activity and cellular recognition.

---

5. Is your PDRN suitable for injectable formulations?
Yes. Our PDRN is pharmaceutical grade and produced under GMP and ISO 13485 standards, ensuring high purity, safety, and consistency for use in aesthetic injectables and medical formulations.

---

6. What certifications does your PDRN have?
Our PDRN is manufactured under certified quality systems including ISO 9001, ISO 22000, HACCP, HALAL, GMPC, and U.S. GRAS recognition, ensuring full compliance with international regulatory standards.

---

7. How is the purity and quality of PDRN controlled?
Each batch undergoes rigorous testing for molecular weight distribution, endotoxin levels, biological activity, and absence of contaminants. This guarantees pharmaceutical-grade purity and consistent performance across all applications.

---

8. What are the benefits of using PDRN in skincare and regenerative products?
PDRN enhances skin elasticity, hydration, and repair, while reducing inflammation and improving wound healing. It helps achieve visible rejuvenation and faster recovery in both cosmetic and medical treatments.

---

9. What is the difference between PDRN and PN (Polynucleotide)?
Both are DNA-based bioactive materials, but PDRN refers to a specific molecular weight range (50–1500 kDa) known for strong regenerative and anti-inflammatory activity, whereas PN may include a broader range of DNA polymers used for hydration and skin texture improvement.

---

10. Can PDRN be customized for different formulations?
Yes. We offer customizable PDRN grades tailored to specific application requirements—whether for injectable solutions, topical formulations, or nutraceutical products—ensuring compatibility and optimal performance in your formulation process.

---

11. Do you provide technical documents and testing data?
Absolutely. We supply COA, MSDS, specifications, test reports, and stability data to support regulatory submissions and product development.

---

12. How should PDRN be stored and handled?
Store PDRN in a cool, dry environment away from direct sunlight. Keep tightly sealed to prevent moisture absorption. Recommended storage temperature: 2–8°C.