Description

Product Name: Crosslinked Sodium Hyaluronate Powder 
Molecular Weight Range: Base HA molecular weight varies; crosslinking creates supramolecular structures with tailored rheological properties
Appearance: White to off-white free-flowing lyophilized powder
Functions:
Long-lasting Dermal Augmentation: Primary API for aesthetic fillers providing sustained volume restoration and facial contouring with 6-18 month persistence
Viscosupplementation: Forms viscoelastic gels for intra-articular injections to restore joint function and provide lubrication in osteoarthritis treatment
Drug Delivery Platform: Serves as an advanced sustained-release matrix for bioactive molecules in regenerative medicine and pharmaceutical applications
Tissue Engineering Scaffold: Provides three-dimensional structure for cellular ingrowth and tissue regeneration in advanced medical applications
Customizable Rheology: Available in different grades (CSHA/CDHA/CWHA) with specific viscoelastic profiles for precise clinical applications
Molecular Formula: (C₁₄H₂₀NO₁₁Na)n
Molecular Weight: Polymer base typically in the million Daltons range; crosslinking creates complex supramolecular architectures

Our Product Superiority: Why Choose Us?

1. Advanced Crosslinking Technology with Superior Safety Profile:
Our proprietary multi-step crosslinking process ensures exceptional product quality with ultralow endotoxin levels (<0.005 EU/mg) and minimal BDDE residues, significantly below regulatory limits. This advanced manufacturing technology eliminates the trade-off between product longevity and safety, delivering both extended duration and excellent biocompatibility for sensitive medical applications.

2. Precision-Engineered Rheological Properties:
We offer three distinct product grades tailored for specific clinical applications:
2.1CSHA (Cohesive Single-phase Gel): High elastic modulus (G’: 1000-1100 Pa) for structural support in deep dermal augmentation
2.2CDHA (Cohesive Dual-phase Gel): Balanced viscoelastic properties (G’: 260-470 Pa) for versatile filling and joint lubrication
2.3CWHA (Cohesive Micro-crosslinked Gel): Lower modulus (G’: 130-300 Pa) for superficial injections and advanced drug delivery systems

3. Global Regulatory Compliance and Certification:
Our manufacturing facilities maintain comprehensive international certifications including FDA compliance, ISO 13485 (Medical Devices), ISO 9001, cGMP, Halal, REACH, ISO 22000, HACCP, FSSC 22000, and COSMOS. This extensive certification portfolio ensures your products meet global regulatory requirements and quality standards for medical device and pharmaceutical applications.

4. Enhanced Stability and Manufacturing Flexibility:
The lyophilized powder format offers significant advantages over pre-formed gels, including:
4.1Extended shelf life and improved stability
4.2Flexible rehydration ratios (0.2%-2.5% depending on grade)
4.3Customizable final product characteristics
4.4Simplified sterilization and manufacturing processes
4.5Reduced shipping and storage costs

5. Complete Technical Support and Customization:
We partner with our clients to develop tailored solutions, offering customization of crosslinking density, particle size distribution, and rheological properties. Our technical team provides comprehensive support from formulation development to regulatory documentation, ensuring successful product commercialization.

Packaging & Storage
1.Packaging: Our product is packaged in double-bagged, vacuum-sealed aluminum pouches within dedicated pharmaceutical-grade containers. All packaging materials are qualified for medical use and designed to maintain product integrity during shipping and storage.
2.Storage: CRITICAL – Store at -15°C or below in a dedicated freezer. Protect from light and moisture. The container must remain sealed until use. Under these conditions, the product maintains stability for 36 months. Allow the product to reach room temperature before opening to prevent condensation.

Reconstitution Instructions:
1.Use only sterile physiological saline for reconstitution
2.Gently agitate to ensure complete hydration and homogeneous gel formation
3.The reconstituted gel should be used immediately in aseptic manufacturing conditions
4..Do not re-sterilize the reconstituted gel
5.Follow specific ratio guidelines for each product grade to achieve desired rheological properties

Cross-linked sodium hyaluronate powder
Specification	CSHA	CDHA	CWHA
GelType	Biphasic	Monophasic	Micro-crosslinked
Usage Ratio	1.0-2.5%	0.5-2.5%	0.2-2.0%
Elastic Modulus(G’)	1000-1100 Pa	260-470 Pa	130-300 Pa
Viscous Modulus (G”)	280-310Pa	50-150Pa	50-150Pa
Applications	Fillers, Drug Carriers	Fillers, Joint Lubrication, Drug Carriers	Mesotherapy Joint Lubrication, (skin booster) Drug Carriers
Storage Temperature	Below-15°C

 

Biphasic Crosslinked Sodium Hyaluronate Gel
Specification	Superficial Layer	MiddleLayer	DeepLayer	Ultra-Deep Layer
Concentration	20-24mg/ml	20-24mg/ml	20-24mg/ml	20-24mg/ml
Syringe Volume	1ml/2ml	1ml/2ml	1ml/2ml	10ml
GelParticle Size(um)	100-300	300-600	500-800	800-1000
Duration	6-12 months	6-12months	6-12 months	12-18months
Indications	Correction of forehead, periorbitaland perioral fine lines	Wrinkle and lip lift treatments	Lip augmentation and faciacontouring (cheeks,jawline)	Breast and buttock augmentation
StorageTemperature	2-8°C

Frequently Asked Questions (FAQ) – Medical Grade Crosslinked Sodium Hyaluronate Powder

1. What is Medical Grade Crosslinked Sodium Hyaluronate Powder?
Answer:
It is a high-performance hyaluronic acid (HA) polymer crosslinked using BDDE and processed into a stable lyophilized powder. Upon rehydration in physiological saline, it restores a robust 3D hydrogel network suitable for medical and aesthetic applications.

2. What are the main applications of this powder?
Answer:
This powder is ideal for:

• Dermal fillers for wrinkle correction and facial contouring

• Intra-articular injections for joint lubrication and tissue regeneration

• Regenerative medicine and advanced drug delivery systems

3. How does crosslinking affect performance?
Answer:
Controlled crosslinking (6%-8% BDDE) enhances longevity, viscoelasticity, and tissue integration while maintaining high biocompatibility. The crosslinked matrix provides in vivo persistence of 6–18 months.

4. How safe is this product for injectable use?
Answer:
Extremely safe. The powder has ultralow endotoxin levels (<0.005 EU/mg) and minimal crosslinker residues. It is manufactured in cGMP-certified facilities and meets FDA and ISO 13485 standards, ensuring pharmaceutical-grade purity.

5. Can this powder be customized for specific formulations?
Answer:
Yes. We offer customization of crosslinking density, particle size, and rheological properties to meet the requirements of dermal fillers, viscosupplements, or other medical formulations.

6. How should the powder be stored and handled?
Answer:
Store in a cool, dry place away from light and moisture. Rehydrate using physiological saline under sterile conditions for injectable applications. Proper storage preserves stability and performance.

7. What makes this powder different from standard sodium hyaluronate?
Answer:
Unlike standard HA, this powder is crosslinked and lyophilized, providing superior stability, long-term persistence, controlled viscoelasticity, and suitability for high-performance medical and aesthetic products.

8. Can it be used in combination with other actives?
Answer:
Yes. Its hydrogel network can serve as a carrier for hydrophilic or compatible therapeutic agents, enhancing delivery and functional performance.

9. What certifications ensure the quality of this product?
Answer:
Manufactured under cGMP with ISO 13485 and FDA compliance, the product guarantees batch-to-batch consistency, ultralow endotoxin levels, and pharmaceutical-grade purity.

10. What is the shelf life of the powder?
Answer:
When stored properly in a cool, dry environment, the lyophilized powder maintains stability for extended periods (typically 24 months), ensuring consistent formulation performance.