Description

Product Name: Crosslinked Sodium Hyaluronate Gel (Medical Grade API)
Molecular Weight Range: Base HA molecular weight varies; crosslinking creates supramolecular structures with tailored rheological properties
Appearance: Clear, transparent viscoelastic gel
Functions:
1.Advanced Dermal Augmentation: Primary API for precision aesthetic fillers providing targeted tissue support and facial contouring with 6-18 month persistence
2.Joint Viscosupplementation: Forms viscoelastic cushions for intra-articular injections to restore joint function and provide lubrication in osteoarthritis treatment
3.Anti-adhesion Barrier: Creates physical barriers to prevent tissue adhesion in minimally invasive surgical procedures
4.Drug Delivery Platform: Serves as an advanced sustained-release matrix for bioactive molecules in pharmaceutical applications
2.Tissue Integration: Promotes natural tissue integration while maintaining structural integrity for predictable clinical outcomes
Molecular Formula: (C₁₄H₂₀NO₁₁Na)n
Molecular Weight: Polymer base typically in the million Daltons range; crosslinking creates complex supramolecular architectures

Our Product Superiority: Why Choose Us?

1. Precision-Engineered Formulations for Targeted Applications:
We offer four specialized gel formulations designed for specific tissue depths and clinical requirements:
1.1Superficial Layer (100-300μm): Perfect for correcting fine lines in the forehead, periorbital and perioral areas with 6-12 month duration
1.2Middle Layer (300-600μm): Ideal for wrinkle treatment and lip enhancement with balanced viscosity and natural integration
1.3Deep Layer (500-800μm): Designed for creating fuller lips and facial contouring in cheeks and chin with structural support
1.4Ultra-Deep Layer (800-1000μm): Formulated for breast augmentation and buttock enhancement with extended 12-18 month longevity

2. Advanced Crosslinking Technology with Superior Safety Profile:
Our proprietary multi-step crosslinking process ensures exceptional product quality with ultralow endotoxin levels and minimal BDDE residues (<1μg/ml), significantly below regulatory limits. This advanced manufacturing technology eliminates the trade-off between product longevity and safety, delivering both extended duration and excellent biocompatibility for sensitive medical applications.

3. Global Regulatory Compliance and Certification:
Our manufacturing facilities maintain comprehensive international certifications including FDA compliance, ISO 13485 (Medical Devices), ISO 9001, cGMP, Halal, REACH, ISO 22000, HACCP, FSSC 22000, and COSMOS. This extensive certification portfolio ensures your products meet global regulatory requirements and quality standards for medical device and pharmaceutical applications across international markets.

4. Optimized Rheological Properties for Clinical Excellence:
Each gel formulation features precisely controlled viscoelastic properties ensuring optimal tissue integration, natural movement, and predictable clinical outcomes. The uniform three-dimensional network structure provides consistent performance across all product variants.

5. Complete Technical Support and Customization:
We partner with our clients to develop tailored solutions, offering customization of crosslinking density, particle size distribution, concentration, and rheological properties. Our technical team provides comprehensive support from formulation development to regulatory documentation, ensuring successful product commercialization and market differentiation.

Cross-linked sodium hyaluronate powder
Specification	CSHA	CDHA	CWHA
GelType	Biphasic	Monophasic	Micro-crosslinked
Usage Ratio	1.0-2.5%	0.5-2.5%	0.2-2.0%
Elastic Modulus(G’)	1000-1100 Pa	260-470 Pa	130-300 Pa
Viscous Modulus (G”)	280-310Pa	50-150Pa	50-150Pa
Applications	Fillers, Drug Carriers	Fillers, Joint Lubrication, Drug Carriers	Mesotherapy Joint Lubrication, (skin booster) Drug Carriers
Storage Temperature	Below-15°C

 

Biphasic Crosslinked Sodium Hyaluronate Gel
Specification	Superficial Layer	MiddleLayer	DeepLayer	Ultra-Deep Layer
Concentration	20-24mg/ml	20-24mg/ml	20-24mg/ml	20-24mg/ml
Syringe Volume	1ml/2ml	1ml/2ml	1ml/2ml	10ml
GelParticle Size(um)	100-300	300-600	500-800	800-1000
Duration	6-12 months	6-12months	6-12 months	12-18months
Indications	Correction of forehead, periorbitaland perioral fine lines	Wrinkle and lip lift treatments	Lip augmentation and faciacontouring (cheeks,jawline)	Breast and buttock augmentation
StorageTemperature	2-8°C

 

Packaging & Storage
1.Packaging: Our product is supplied in ready-to-use sterile glass syringes (1ml, 2ml, 10ml) with tamper-evident packaging. All packaging components are medically certified and validated for compatibility with the gel formulation.
2.Storage: CRITICAL – Store at 2-8°C in a dedicated medical refrigerator. Protect from freezing and direct light. Do not expose to high temperatures. The product should remain in its original packaging until use. Under these conditions, the product maintains stability for 24 months.

Handling Instructions:
1.Always maintain the cold chain during storage and transportation
2.Allow the product to reach room temperature naturally before use
3.Do not resterilize the syringes or transfer the gel to other containers
4.Use aseptic techniques during clinical application
5.Follow specific clinical guidelines for each product variant and indication

Crosslinked Sodium Hyaluronate Gel (Medical Grade) – FAQ

1. What is Crosslinked Sodium Hyaluronate Gel (Medical Grade)?
Answer:
It is a high-purity, crosslinked hyaluronic acid (HA) gel designed for advanced medical and aesthetic applications. The gel is produced using multi-step crosslinking technology, forming a stable three-dimensional network with controlled crosslinking density (6%-8%), resulting in a long-lasting, viscoelastic gel suitable for precision treatments.

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2. What are the main applications of this gel?
Answer:
Our crosslinked HA gel is specifically formulated for:

• Precision aesthetic contouring (dermal fillers for fine lines, volume restoration, and facial sculpting)

• Joint viscosupplementation for osteoarthritis management

• Minimally invasive anti-adhesion treatments in surgical procedures

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3. What formulations are available, and how are they different?
Answer:
We offer four specialized formulations targeting different tissue depths:

• Superficial: For fine lines and delicate tissue

• Middle: For moderate wrinkles and soft tissue support

• Deep: For volume restoration and deeper facial contouring

• Ultra-Deep: For advanced volumization and structural support
  Each formulation has optimized particle size (100-1000μm) and concentration (20-24mg/ml) to meet specific clinical needs.

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4. How long does the gel last in vivo?
Answer:
The viscoelastic gel demonstrates excellent longevity, maintaining effects for 6-18 months, depending on the treatment area and patient metabolism.

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5. What is the safety profile of this product?
Answer:

• Manufactured in cGMP-certified facilities with FDA and ISO 13485 compliance

• Ultra-low endotoxin levels

• Minimal BDDE crosslinker residues (<1 μg/ml)

• Fully biocompatible, ensuring safety for medical and aesthetic applications

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6. Can the product be customized?
Answer:
Yes. Our technical expertise allows customization of:

• Crosslinking density

• Particle size distribution

• Rheological properties (viscosity, elasticity)
  This ensures the gel can meet your specific product or treatment requirements.

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7. What quality certifications does the gel have?
Answer:

• cGMP-compliant manufacturing

• ISO 13485 certified

• FDA compliance
  These certifications ensure pharmaceutical-grade quality suitable for global medical and aesthetic markets.

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8. What are the storage and handling recommendations?
Answer:

• Store at 2-25°C in a dry, shaded environment

• Avoid freezing or excessive heat

• Use sterile techniques when handling for medical applications to maintain product integrity

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9. Is this gel suitable for use in medical devices or combination products?
Answer:
Yes. Its purity, biocompatibility, and customizable properties make it an ideal foundation for dermal fillers, viscosupplementation products, and advanced medical devices requiring high safety and performance standards.

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10. How can I request samples or technical specifications?
Answer:
Please contact our sales team or technical support for detailed product datasheets, Certificates of Analysis (CoA), and sample requests for evaluation.