Description

Crosslinked Sodium Hyaluronate Gel – Medical Grade Injectable Material
Crosslinked Sodium Hyaluronate Gel is an advanced biomaterial designed for precision medical and aesthetic applications. By applying multi-crosslinking technology, the product achieves a highly stable three-dimensional network that enhances resistance to enzymatic degradation and ensures long-lasting performance in vivo.
This product is widely used in dermal fillers, orthopedic viscosupplementation, and post-surgical anti-adhesion solutions, making it a versatile material for both medical and aesthetic industries.

1.Core Technology – Multi-Crosslinking System
The gel is developed using a controlled crosslinking process that ensures:
• Crosslinking degree precisely controlled between 6%–8% (customizable)
• Uniform and stable 3D network structure
• Excellent viscoelastic properties
• Low endotoxin levels
• Ultra-low BDDE residue (<1 μg/ml)
This optimized network structure enhances mechanical strength while maintaining injectability and biocompatibility.

2.Key Functional Benefits
2.1Long-Lasting Effect
Crosslinking significantly slows enzymatic degradation, allowing the gel to remain effective for 6–18 months depending on application.
2.2Precise Contouring and Shaping
The gel maintains structural integrity after injection, enabling accurate facial sculpting and volumization.
2.3High Biocompatibility
As a naturally occurring substance in the human body, hyaluronic acid ensures excellent tolerance and safety.
2.4Superior Viscoelasticity
The balanced elasticity and viscosity make it suitable for both aesthetic filling and medical lubrication.
2.5Safety and Purity
Low residual crosslinking agent and controlled impurities ensure compliance with strict medical-grade standards.

3.Product Specifications
3.1Injection Depth & Particle Size
Superficial Layer: 100–300 μm
Middle Layer: 300–600 μm
Deep Layer: 500–800 μm
Ultra-Deep Layer: 800–1000 μm
3.2Concentration
20–24 mg/ml (customizable)
3.3Syringe Volume
1 ml / 2 ml / 10 ml (customizable formats)
3.4Duration
6–12 months (superficial to deep)
12–18 months (ultra-deep)
3.5Storage Conditions
2–8°C, protected from light

4.Application Areas
4.1Aesthetic Medicine
fine lines correction
lip enhancement
facial contouring
nasolabial folds
cheek augmentation
chin shaping
deep wrinkle filling
4.2Medical Applications
joint lubrication (viscosupplementation)
post-surgical anti-adhesion
soft tissue repair

5.Customization (OEM / ODM)
Tailored solutions are available for global partners:
custom crosslinking degree
particle size adjustment
viscosity and rheology tuning
private label packaging
application-specific formulations

6.Quality & Regulatory Compliance
Manufactured under strict international standards:
ISO13485
ISO9001
cGMP
HACCP
FSSC22000
REACH
Halal & Kosher
Ensures global market compatibility and regulatory acceptance.

7.Manufacturing Process Overview
Step 1: Raw sodium hyaluronate preparation
Step 2: Controlled crosslinking reaction
Step 3: Formation of 3D gel network
Step 4: Purification and removal of residual agents
Step 5: Homogenization and particle sizing
Step 6: Sterile filling
Step 7: Final inspection and packaging

8.Packaging & Storage
Sterile prefilled syringes
Cold-chain transportation recommended
Store at 2–8°C

Cross-linked sodium hyaluronate powder
Specification	CSHA	CDHA	CWHA
GelType	Biphasic	Monophasic	Micro-crosslinked
Usage Ratio	1.0-2.5%	0.5-2.5%	0.2-2.0%
Elastic Modulus(G’)	1000-1100 Pa	260-470 Pa	130-300 Pa
Viscous Modulus (G”)	280-310Pa	50-150Pa	50-150Pa
Applications	Fillers, Drug Carriers	Fillers, Joint Lubrication, Drug Carriers	Mesotherapy Joint Lubrication, (skin booster) Drug Carriers
Storage Temperature	Below-15°C

 

Biphasic Crosslinked Sodium Hyaluronate Gel
Specification	Superficial Layer	MiddleLayer	DeepLayer	Ultra-Deep Layer
Concentration	20-24mg/ml	20-24mg/ml	20-24mg/ml	20-24mg/ml
Syringe Volume	1ml/2ml	1ml/2ml	1ml/2ml	10ml
GelParticle Size(um)	100-300	300-600	500-800	800-1000
Duration	6-12 months	6-12months	6-12 months	12-18months
Indications	Correction of forehead, periorbitaland perioral fine lines	Wrinkle and lip lift treatments	Lip augmentation and faciacontouring (cheeks,jawline)	Breast and buttock augmentation
StorageTemperature	2-8°C

Crosslinked Sodium Hyaluronate FAQ

1. What is crosslinked sodium hyaluronate?

Crosslinked sodium hyaluronate is a chemically modified form of hyaluronic acid designed to provide enhanced stability, improved viscoelasticity, and longer-lasting performance compared with non-crosslinked hyaluronic acid.

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2. What is the typical crosslinking degree?

The standard crosslinking degree is typically between 6% and 8%, and can be adjusted based on formulation requirements and application needs.

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3. How long does crosslinked sodium hyaluronate last in vivo?

Its duration generally ranges from 6 to 18 months depending on injection depth, formulation design, particle size, and treatment area.

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4. What is the residual BDDE level?

The residual BDDE content is strictly controlled below 1 μg/ml to meet international safety standards for medical aesthetic applications.

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5. Is crosslinked sodium hyaluronate suitable for dermal fillers?

Yes, it is widely used in dermal filler manufacturing due to its excellent viscoelasticity, stability, and volumizing performance.

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6. Can it be used for orthopedic joint injections?

Yes, crosslinked sodium hyaluronate is commonly used in viscosupplementation products for osteoarthritis and joint lubrication therapy.

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7. Do you offer OEM/ODM services?

Yes, we provide full OEM/ODM customization including formulation adjustment, concentration customization, packaging design, and private labeling services.

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8. What certifications are available?

Available certifications include ISO, GMP, Halal, Kosher, and other compliance documents based on customer requirements and destination markets.

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9. Is the product sterile?

Yes, the product is manufactured under sterile production conditions and can meet medical-grade sterility requirements.

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10. What packaging options do you provide?

We offer multiple packaging options including prefilled syringes, sterile vials, and customized packaging formats in various sizes.