Description

Crosslinked Sodium Hyaluronate Powder – Advanced Lyophilized HA for Medical & Aesthetic Applications
Crosslinked Sodium Hyaluronate Powder represents a next-generation form of hyaluronic acid biomaterial, combining advanced crosslinking chemistry with freeze-drying technology to deliver superior stability, flexibility, and performance.
Designed for global B2B manufacturers, this material enables the development of high-end dermal fillers, joint injection products, and regenerative medicine formulations with consistent quality and customizable properties.

1.Core Technology: BDDE Multi-Crosslinking + Freeze-Drying
This product is manufactured using a controlled BDDE crosslinking process followed by lyophilization:
• Crosslinking degree precisely controlled at 6%–8%
• Uniform three-dimensional network formation
• Enhanced resistance to enzymatic degradation
• Freeze-dried structure ensures long-term stability
• Instant rehydration into viscoelastic gel
The combination of crosslinking and lyophilization ensures that the material maintains its structural integrity while offering flexibility in downstream processing.

2.Key Advantages
2.1Long-Lasting In Vivo Performance
The crosslinked network significantly slows degradation, providing a duration of 6–18 months depending on formulation.
2.2Flexible Formulation Capability
Unlike prefilled gels, the powder allows manufacturers to design customized formulations based on viscosity, elasticity, and application needs.
2.3Ultra-Low Endotoxin Level
<0.005 EU/mg, suitable for high-end medical and injectable applications.
2.4Rapid Reconstitution
Restores original gel structure immediately after mixing with saline.
2.5Stable Supply & Storage
Freeze-dried format ensures long shelf life and convenient transportation.

3.Product Types & Technical Parameters
3.1Product Grades
CSHA – Biphasic Crosslinked HA
CDHA – Monophasic Crosslinked HA
CWHA – Micro-Crosslinked HA
3.2Rheological Properties
Elastic Modulus (G’):
CSHA: 1000–1100 Pa
CDHA: 260–470 Pa
CWHA: 130–300 Pa
Viscous Modulus (G”):
CSHA: 280–310 Pa
CDHA: 50–150 Pa
CWHA: 50–150 Pa
3.3Recommended Usage Ratio
CSHA: 1.0% – 2.5%
CDHA: 0.5% – 2.5%
CWHA: 0.2% – 2.0%
3.4Storage Conditions
Store below -15°C
Keep dry and protected from light

4.Application Fields
4.1Medical Aesthetics
dermal filler manufacturing
facial contouring products
long-lasting injectable gels
4.2Orthopedic Applications
joint lubrication formulations
viscosupplementation
4.3Regenerative Medicine
drug delivery carriers
microsphere composite systems
tissue engineering
4.4Pharmaceutical Industry
controlled-release formulations
biocompatible excipients

5.OEM & Customization Services
This product supports full customization:
crosslinking degree
particle size
viscosity profile
application-specific solutions
private label packaging

6.Quality & Certifications
Produced under strict international systems:
ISO13485
ISO9001
cGMP
REACH
HACCP
FSSC22000
Halal & Kosher
Ensuring global compliance and consistent batch quality.

7.Manufacturing Process Overview
Step 1: Sodium hyaluronate raw material preparation
Step 2: BDDE crosslinking reaction
Step 3: Formation of 3D gel network
Step 4: Purification & detoxification
Step 5: Freeze-drying (lyophilization)
Step 6: Milling & particle control
Step 7: Packaging

8.Packaging & Logistics
Moisture-proof packaging
Cold-chain storage recommended
Custom packaging available

Cross-linked sodium hyaluronate powder
Specification	CSHA	CDHA	CWHA
GelType	Biphasic	Monophasic	Micro-crosslinked
Usage Ratio	1.0-2.5%	0.5-2.5%	0.2-2.0%
Elastic Modulus(G’)	1000-1100 Pa	260-470 Pa	130-300 Pa
Viscous Modulus (G”)	280-310Pa	50-150Pa	50-150Pa
Applications	Fillers, Drug Carriers	Fillers, Joint Lubrication, Drug Carriers	Mesotherapy Joint Lubrication, (skin booster) Drug Carriers
Storage Temperature	Below-15°C

 

Biphasic Crosslinked Sodium Hyaluronate Gel
Specification	Superficial Layer	MiddleLayer	DeepLayer	Ultra-Deep Layer
Concentration	20-24mg/ml	20-24mg/ml	20-24mg/ml	20-24mg/ml
Syringe Volume	1ml/2ml	1ml/2ml	1ml/2ml	10ml
GelParticle Size(um)	100-300	300-600	500-800	800-1000
Duration	6-12 months	6-12months	6-12 months	12-18months
Indications	Correction of forehead, periorbitaland perioral fine lines	Wrinkle and lip lift treatments	Lip augmentation and faciacontouring (cheeks,jawline)	Breast and buttock augmentation
StorageTemperature	2-8°C

Crosslinked Hyaluronic Acid Powder FAQ

1. What is crosslinked hyaluronic acid powder?

Crosslinked hyaluronic acid powder is a freeze-dried form of chemically modified sodium hyaluronate. It is widely used as a premium raw material in dermal fillers, injectable formulations, tissue engineering, and pharmaceutical delivery systems.

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2. What is the difference between crosslinked hyaluronic acid powder and gel?

The main difference is physical form and processing flexibility. Powder offers better storage stability, easier transportation, longer shelf life, and allows manufacturers to formulate products according to customized concentration requirements.

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3. What is the typical crosslinking degree of crosslinked hyaluronic acid powder?

The standard crosslinking degree usually ranges from 6% to 8%, depending on the intended medical or cosmetic application and formulation needs.

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4. How do you use crosslinked hyaluronic acid powder?

Crosslinked hyaluronic acid powder is typically reconstituted with sterile saline or purified water before formulation or application, based on the desired viscosity and product requirements.

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5. What is the endotoxin specification of your crosslinked hyaluronic acid powder?

Our standard endotoxin specification is below 0.005 EU/mg, meeting strict quality standards for high-end injectable and biomedical applications.

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6. What is crosslinked hyaluronic acid powder used for?

It is commonly used in dermal filler production, osteoarthritis joint injections, wound healing materials, biomedical scaffolds, tissue engineering, and controlled drug delivery systems.

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7. Can crosslinked hyaluronic acid powder be customized?

Yes. We offer OEM/ODM customization services including molecular weight adjustment, particle size control, crosslinking degree modification, and customized packaging solutions.

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8. How should crosslinked hyaluronic acid powder be stored?

It should be stored below -15°C in a sealed, dry, and light-protected environment to maintain maximum stability and product performance.

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9. Is your crosslinked hyaluronic acid powder sterile?

Yes, both sterile and non-sterile grades are available depending on your formulation and manufacturing requirements.

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10. What certifications do you provide for crosslinked hyaluronic acid powder?

We can provide certifications such as ISO, GMP, Halal, Kosher, and REACH compliance based on customer and regional market requirements.