Description

Product Name: Polynucleotide (PN) API
Molecular Weight Range: 100-2000 kDa (with optimized distribution for enhanced tissue integration and prolonged activity)
Appearance: White to off-white lyophilized powder or fibrous material, highly soluble in aqueous solutions
Functions:
1.Advanced Tissue Regeneration: Stimulates fibroblast proliferation and activates collagen types I and III synthesis, significantly improving skin density and mechanical properties
2.Cellular Energy Optimization: Enhances mitochondrial function and ATP production, supporting cellular metabolism and tissue vitality
3.Anti-inflammatory Modulation: Regulates key inflammatory mediators including IL-6, TNF-α, and prostaglandins, reducing inflammation and promoting tissue homeostasis
4.Angiogenesis Stimulation: Promotes new blood vessel formation through VEGF upregulation, enhancing tissue oxygenation and nutrient delivery
5.Extracellular Matrix Restoration: Increases hyaluronic acid synthesis and proteoglycan production, improving skin hydration and mechanical properties
6.DNA Repair Support: Provides nucleotide precursors for cellular repair mechanisms, protecting against environmental damage and oxidative stress
Molecular Formula: (C₁₀H₁₂N₅O₇P·C₉H₁₂N₃O₇P)n
Molecular Weight: Typically 100-2000 kDa (precisely controlled for optimal therapeutic performance)

Our Product Superiority: Why Choose Us?

1. Scientifically Validated Performance:
Our PN undergoes comprehensive biological activity validation using advanced in vitro and ex vivo models. Through sophisticated chromatography techniques, we ensure optimal molecular weight distribution that maximizes tissue integration and sustained release properties. Each batch is tested for its ability to stimulate fibroblast activity, collagen production, and extracellular matrix enhancement, guaranteeing consistent performance in final formulations.

2. Global Regulatory Compliance:
We maintain an unparalleled commitment to quality with ISO 9001, ISO 22000, HACCP, HALAL, GMPC, and U.S. GRAS certifications. This extensive certification portfolio demonstrates our dedication to manufacturing excellence and provides our global clients with confidence in our ability to meet international regulatory requirements across pharmaceutical, cosmetic, and nutraceutical markets. Our documentation support ensures seamless integration into your regulatory submissions worldwide.

3. Advanced Manufacturing Technology:
Utilizing state-of-the-art purification and fractionation technologies, we produce PN with exceptional purity and consistent biological activity. Our proprietary process eliminates impurities while preserving the structural integrity of the polynucleotide chains, resulting in superior performance characteristics. The manufacturing process includes multiple validation steps to ensure batch-to-batch consistency and reliable therapeutic outcomes.

4. Multi-Industry Application Expertise:
Our PN API is engineered for seamless integration across diverse product categories:
4.1Aesthetic Medicine: Injectable skin boosters, mesotherapy formulations, and biorevitalization treatments
4.2Advanced Dermocosmetics: High-performance anti-aging products, regenerative serums, and premium skincare lines
4.3Wound Management: Advanced healing gels, post-procedural recovery products, and chronic wound treatments
4.4Nutraceutical Innovations: Oral supplements for skin health, joint support, and overall cellular vitality
4.5Medical Devices: Coatings for implants and materials promoting tissue integration

5. Comprehensive Technical Partnership:
We provide extensive technical support including formulation guidance, stability testing protocols, and regulatory documentation assistance. Our customization options include specific molecular weight profiles, concentration optimization, and compatibility testing with various delivery systems. We partner with clients through the entire product development cycle, from initial concept to commercial manufacturing, ensuring your products achieve market success and clinical excellence.

 

Packaging & Storage
1.Packaging: Our PN is packaged in sterile, nitrogen-filled glass vials with pharmaceutical-grade butyl rubber stoppers and aluminum crimp seals. Available in 100mg, 500mg, 1g, and 5g vials, with custom bulk packaging options tailored to your manufacturing requirements. All packaging components undergo rigorous compatibility and extractables testing.
2.Storage: CRITICAL – Store at -20°C or below in a temperature-monitored environment. Protect from light and moisture exposure. Maintain containers sealed under inert atmosphere until use. Under validated conditions, the product maintains stability for 36 months. Avoid repeated freeze-thaw cycles. For manufacturing use, reconstitute with appropriate sterile solvent immediately before incorporation into final formulations.

 

Handling Instructions:
1.Maintain unbroken cold chain during storage and transportation with temperature monitoring
2.Equilibrate to room temperature in sealed condition before opening to prevent condensation
3.Use aseptic techniques during handling and reconstitution procedures
4.Reconstitute immediately before use and avoid extended storage of prepared solutions
5.For cosmetic applications, incorporate during final manufacturing stages under controlled conditions
6.Use appropriate solvent systems compatible with polynucleotide structure and activity

Polynucleotide (PN) – Frequently Asked Questions (FAQ)

1. What is Polynucleotide (PN)?
Polynucleotide (PN) is a bioactive DNA polymer composed of purified nucleotide chains derived through advanced biotechnological processes. It serves as a regenerative ingredient that promotes cellular repair, tissue regeneration, and skin rejuvenation in aesthetic and pharmaceutical formulations.

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2. How does PN work in the body?
PN interacts with multiple cellular signaling pathways, activating fibroblasts and stimulating collagen, elastin, and extracellular matrix production. It also regulates cytokine activity to reduce inflammation, support angiogenesis, and accelerate tissue repair.

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3. What are the main applications of PN?
PN is widely used in:

• Aesthetic injectables for skin revitalization and anti-aging.

• Regenerative skincare formulations to enhance elasticity and barrier function.

• Wound healing and medical therapies for faster tissue recovery.

• Nutraceuticals aimed at promoting cellular regeneration and hydration.

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4. What is the molecular weight range of your PN?
Our Pharmaceutical Grade PN features DNA fragments with molecular weights between 100–2000 kDa, optimized for high bioavailability and sustained biological activity in topical and injectable formulations.

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5. How is PN different from PDRN (Polydeoxyribonucleotide)?
While both PN and PDRN are DNA-based regenerative materials, PN has a broader molecular weight range and provides stronger hydration and elasticity effects, whereas PDRN primarily focuses on tissue repair and anti-inflammatory action. PN is often preferred in cosmetic and anti-aging applications, while PDRN is favored for medical and wound-healing uses.

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6. Is your PN suitable for injectable formulations?
Yes. Our PN is pharmaceutical grade, manufactured under GMP, ISO 13485, and sterile conditions, ensuring it meets the highest safety and purity standards for aesthetic and medical injectables.

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7. What certifications does your PN have?
Our PN is produced under ISO 9001, ISO 22000, HACCP, HALAL, GMPC, and U.S. GRAS certifications, ensuring compliance with global pharmaceutical and cosmetic regulatory standards.

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8. How do you ensure the quality and consistency of PN?
Each batch undergoes strict testing for:

• Molecular weight distribution

• Biological activity

• Endotoxin and heavy metal levels

• Sterility and purity
  This ensures batch-to-batch consistency, stability, and high efficacy in all applications.

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9. What are the benefits of using PN in skincare or aesthetic formulations?
PN promotes skin firmness, hydration, and elasticity while improving texture, tone, and barrier function. It also helps reduce wrinkles, repair damaged skin, and accelerate post-procedure recovery, making it a preferred active for high-end anti-aging treatments.

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10. Can PN be combined with other active ingredients?
Yes. PN can be effectively combined with hyaluronic acid, peptides, vitamins, and growth factors to enhance hydration, regeneration, and skin rejuvenation outcomes in both injectable and topical products.

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11. Do you provide technical documentation and analytical data?
Yes. We provide comprehensive COA, MSDS, specification sheets, stability data, and testing reports to support product development, quality evaluation, and regulatory compliance.

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12. How should PN be stored and handled?
Store PN in a cool, dry, and light-protected environment at 2–8°C. Keep sealed to prevent contamination and moisture absorption. Follow standard handling procedures for sterile biopolymers.