Description

Product Name: Crosslinked Sodium Hyaluronate Polymer API
Molecular Weight Range: Varies based on crosslinking density and base HA ~3,000,000 Da as per QC data). Custom molecular weights available.
Appearance: White to off-white free-flowing powder or granules
Functions:
1.Dermal Filling & Volumizing: The primary API for injectable fillers, providing long-lasting tissue support, wrinkle smoothing, and facial contour restoration.
2.Enhanced Moisturization: Forms a dense, hydrating film on the skin, binding water more effectively than native HA for prolonged hydration.
3.Viscoelastic Agent: Imparts superior cushioning and lubrication, ideal for advanced OVDs (Ophthalmic Viscosurgical Devices) and protective skincare formulations.
4.Sustained Release Matrix: Its crosslinked network acts as an advanced delivery system for the controlled release of active ingredients in cosmetics and topical pharmaceuticals.
5.Free-Radical Scavenger: Helps protect the skin from oxidative stress induced by UV exposure and environmental pollutants.
6.Stabilizer & Thickener: Provides excellent rheological control in creams, lotions, gels, and serums, even at low concentrations.

Molecular Formula: (C₁₄H₂₀NO₁₁Na)n
Molecular Weight: Varies; a high-molecular-weight polymer (Base HA typically in the millions of Daltons, with crosslinking creating a supramolecular structure).

Our Product Superiority: Why Choose Us?

1. Unmatched Purity and Quality Specifications:
Our commitment to quality is evidenced by our rigorous specifications that far exceed industry standards.
1.1High Glucuronic Acid Content (47.07%): Directly correlates with high HA purity (>97%), ensuring optimal biological activity and performance.
1.2Exceptionally Low Protein (<0.05%) and Endotoxin (<0.07 EU/mg): Drastically reduces the risk of immunogenic reactions and inflammatory responses, which is critical for injectable and sensitive skin applications.
1.3Superior Clarity and Solubility: Produces a crystal-clear solution with 100% transmittance, essential for elegant, high-clarity formulations and injectable products.
1.4Heavy Metals Control: Arsenic <0.01 ppm, Lead <0.02 ppm, ensuring the highest level of consumer safety.

2. Superior Hydrolytic Stability:
Our crosslinking technology yields a polymer with exceptional resistance to breakdown. In stability tests, our product maintains viscosity for 3-5 days under ambient conditions, whereas competing products show significant viscosity loss. This translates to a longer-lasting effect in dermal fillers and improved shelf-life for your cosmetic formulations.

3. Transparency and Reliability:
We provide actual measured molecular weight values, not just broad ranges. This transparency saves you valuable R&D time, ensures precise formulation, and guarantees consistency in your final product’s performance.

4. Optimal pH and Safety Profile:
Our polymer is consistently buffered to a skin-friendly pH of 6-7, completely avoiding the irritation risks associated with high pH or excessive protein content found in inferior products.

5. Global Certifications and cGMP Compliance:
Our manufacturing is backed by ISO 9001, HACCP, GMP, and ISO 14001 certifications. This robust quality management system provides you with the assurance of a traceable, auditable, and reliable supply chain for global market entry.

Certificate of Analysis (COA)

Parameter	Requirement	Test Result
Appearance	White to pale yellow powder or granules	Compliant
Infrared Absorption	Must match reference spectrum	Compliant
Sodium Salt Identification	Positive reaction	Compliant
Glucuronic Acid (%)	≥45.0	47.07
Sodium Hyaluronate Content (%)	≥92.0	97.32
Average Relative Molecular Mass	Measured value 80–120% of labeled	3021
Absorbance (5mg/ml, H2O, 280nm)	≥99.0	0.045
Solution Transmittance (%)	≤0.25	100
Loss on Drying (%)	≤10.0	7.72
pH (5mg/ml)	5.0–8.5	6.08
Heavy Metals (as Al, mg/kg)	≤20	<20
Protein (%)	≤0.10	0.012
Total Bacterial Count (CFU/g)	≤100	<10
Yeast & Mold (CFU/g)	≤50	<10
Staphylococcus aureus	Not detected	ND
Pseudomonas aeruginosa	Not detected	ND

 

Packaging & Storage
1.Packaging: To prevent moisture absorption and contamination, our product is sealed in double-layer polyethylene bags within dedicated cardboard drums. Custom packaging options are available to meet your specific needs.
2.Storage: CRITICAL – Store in a cool, dry, and well-ventilated place. The container must be kept tightly sealed. Protect from light and moisture. For optimal long-term stability, store at 2°C to 8°C (refrigerated). Allow the product to reach room temperature before opening to prevent condensation.

Handling Instructions:
1.Use only purified or distilled water for dissolution to ensure maximum clarity.
2.Once dissolved, use the solution immediately or add a suitable preservative to prevent microbial growth.
3.Do not mix with cationic surfactants or preservatives, as this will cause incompatibility and precipitation.
4.The product is hygroscopic; handle in a low-humidity environment if possible.

Frequently Asked Questions (FAQ) – Crosslinked Sodium Hyaluronate Polymer

1. What is Crosslinked Sodium Hyaluronate Polymer?
Answer:
Crosslinked Sodium Hyaluronate Polymer is an advanced form of hyaluronic acid (HA) that has been chemically crosslinked to create a three-dimensional gel network. This process enhances water retention, viscoelasticity, and stability against enzymatic and free-radical degradation, making it ideal for medical, cosmetic, and skincare applications.

2. What are the main applications of this polymer?
Answer:
This polymer is widely used in:

• Dermal fillers for wrinkle correction, facial contouring, and tissue volume enhancement

• High-end skincare formulations as a moisturizer and delivery system for active ingredients

• Sun care and hair care products for film-forming and thickening properties

• Other pharmaceutical or cosmeceutical formulations requiring stable, high-performance HA

3. How does crosslinking improve the polymer’s performance?
Answer:
Crosslinking transforms linear HA molecules into a robust 3D gel network. This increases:

• Water-binding capacity for superior hydration

• Viscoelasticity for better tissue integration in injectables

• Resistance to enzymatic breakdown and oxidative damage, ensuring long-lasting effects

4. What is the molecular weight and purity of the polymer?
Answer:
We provide verified molecular weight data for transparency. The polymer also meets strict quality standards, including:

• Glucuronic acid content: >46%

• Protein content: <0.05%

• Ultra-low endotoxin level: <0.07 EU/mg
  This ensures pharmaceutical-grade purity and batch-to-batch consistency.

5. Is the polymer safe for medical and cosmetic use?
Answer:
Yes. Manufactured in ISO 9001, HACCP, and GMP-certified facilities, the polymer meets the highest safety and quality standards. Its low protein and endotoxin levels make it highly suitable for injectables, skincare, and other sensitive formulations.

6. Can this polymer be used in injectable dermal fillers?
Answer:
Absolutely. Its viscoelasticity, tissue integration, and stability make it ideal for dermal fillers, providing sustained volume and long-lasting wrinkle correction.

7. How is this polymer different from standard sodium hyaluronate?
Answer:
Unlike standard sodium hyaluronate, which is linear and more prone to degradation, the crosslinked polymer has a three-dimensional structure. This enhances hydration, longevity, and mechanical properties, making it more effective in high-performance medical and cosmetic applications.

8. Can it be used as a delivery system for other actives?
Answer:
Yes. Its gel network can encapsulate both hydrophilic and lipophilic actives, improving their stability and controlled release in skincare, hair care, and cosmetic formulations.

9. How should the polymer be stored?
Answer:
Store in a cool, dry place, away from direct sunlight and strong oxidizing agents. Proper storage ensures long-term stability and maintains its physicochemical properties.

10. Do you provide technical support or formulation guidance?
Answer:
Yes. We provide detailed specifications, technical datasheets, and formulation support to help partners optimize product performance and ensure compatibility with other ingredients.